Publications
2021
- J. Methorst, N. van hilten, H.J. Risselada,
Inverse design of cholesterol attracting transmembrane helices reveals a paradoxical role of hydrophobic length
bioRxiv 2021.07.01.450699, 2021 - T. John, J. Adler, C. Elsner. J. Petzold, M. Krueger, L.L. Martin, D. Huster, H.J. Risselada, B. Abel,
Size Matters: A Mechanistic Model of Nanoparticle Curvature Effects on Amyloid Fibril Formation
bioRxiv 2021.07.01.450782, 2021 - D. Mehner-Breitfeld, M.T. Ringel, D.A. Tichy, L.J. Endter, K.S. Stroh, H. Luensdorf, H.J. Risselada, Thomas Brueser
TatA and TatB generate a hydrophobic mismatch that is important for function and assembly of the Tat translocon in Escherichia coli
bioRxiv 2021.05.26.445790 (→eLife), 2021 - K.S Stroh, H.J. Risselada
Quantifying membrane curvature sensing of peripheral proteins by simulated buckling and umbrella sampling
in press (JCTC), 2021 - H.J. Risselada
A coarse-grained force-field with an eye for atomic detail
Nature Methods, 18(4):342-343, 2021
2020
- H.J. Risselada, H. Grubmüller
How proteins open fusion pores: Insights from molecular simulations
Eu. Biophys. J., 50(2):279-293, 2020 (Special issue attributed to the ending of DFG SFB803) - Laura J. Endter, H.J. Risselada
Where are those lipidic nano rings?
J. Colloid Interface Sci., 587:789-796, 2020 - Laura J. Endter, Y.G.Smirnova, H.J. Risselada
Density Field Thermodynamic Integration (DFTI): A ’soft’ approach to calculate the free energy of surfactant self-assemblies
J. Phys. Chem. B, 124(31):6775–6785, 2020 - N. van Hilten, K.F. Stroh, H.J. Risselada
Membrane Thinning Induces Sorting of Lipids and the Amphipathic Lipid Packing Sensor (ALPS) Protein Motif
Front. Phys., 11:250, 2020 - L.A. Belyaeva, L. Jiang, A. Soleimani, J. Methorst, H.J. Risselada, G.F. Schneider
Liquids relax and unify strain in graphene
Nat. Comm. 11(898), 2020 - E.M. Blokhuis, M. D'Agostino, A. Mayer, H.J. Risselada
Fusion pores live on the edge
J. Chem. Phys. Lett., 11(4):1204–1208, 2020 - T. John, J. Bandak, N. Sarveson, C. Hackl, H.J. Risselada, A. Prager, C. Elsner, B. Abel
Growth, Polymorphism, and Spatially Controlled Surface Immobilization of Biotinylated Variants of IAPP21-27 Fibrils
bio Macromolecules, 21(2):783–792, 2020 - H.J.Risselada, A. Mayer
SNAREs, tethers and SM proteins: How to overcome the final barriers to membrane fusion?
Biochem. J., 477(1):243-258, 2020
2019
- V. Zoni, V. Nieto, L.J. Endter, H.J. Risselada, L. Monticelli, S. Vanni
To Bud or Not to Bud: A Perspective on Molecular Simulations of Lipid Droplet Budding
Front. Mol. Biosci., 6(124), 2019 - H.J. Risselada
Cholesterol: The Plasma Membrane’s Constituent that Chooses Sides.
Biophys. J., 116(12): 2235--2236, 2019. - Y.G. Smirnova, H.J. Risselada, M. Müller
Thermodynamically reversible paths of the first fusion intermediate reveal an important role for membrane anchors of fusion proteins
PNAS 116(7): 2571-2576, 2019
2018
- T. John, A. Gladytz, C. Kubeil, L.L. Martin, H.J. Risselada, and B. Abel
Impact of nanoparticles on amyloid peptide and protein aggregation: a review with a focus on gold nanoparticles
Nanoscale 10(45):20894-20913, 2018 - M. D'Agostino, H. J. Risselada, L. Endter, and A. Mayer
SNARE-mediated membrane fusion arrests at fusion pore expansion to regulate the volume of an organelle
Embo J. 37(19): e99193, 2018 - H. Grubmüller, R. Jahn, H. J. Risselada
Steric and energetic challenges in SNARE-mediated fusion of membranes
J. Phys. D: Appl. Phys. 51: 343001, 2018 (theme "The 2018 biomembrane curvature and remodeling roadmap")
2017
- M. D'Agostino, H. J. Risselada, A. Lürick, C. Ungermann, and A. Mayer
A tethering complex drives the terminal stage of SNARE-dependent membrane fusion
Nature, 551: 634-638, 2017 - H.J. Risselada
Membrane fusion stalks and 'lipid rafts': A love-hate Relationship
Biophysical J. (Letter), 112(12): 2475-2478, 2017
2016
- G. Bubnis, H.J. Risselada, H. Grubmüller
Exploiting Lipid Permutation Symmetry to Compute Membrane Remodeling Free Energies
Phys. Rev. Lett., 117:188102, 2016 - M. D'Agostino, H.J. Risselada, A. Mayer
Steric hindrance of SNARE transmembrane domain organization impairs the hemifusion-to-fusion transition
EMBO reports, 17(11):1590-1608, 2016 - A. Gladytz, B. Abel, H.J. Risselada
Gold-Induced Fibril Growth:The Mechanism of Surface-Facilitated Amyloid Aggregation
Angew. Chem. Int. Ed. 55:12242-46, 2016 - A. Gladytz, T. John, T. Gladytz, R. Hassert, M. Pagel, S. Naumov, H.J. Risselada, S. Naumov, A.G. Beck-Sickinger, B. Abel,
Peptides@mica: from affinity to adhesion mechanism
Phys. Chem. Chem. Phys., 18:23516-23527, 2016
2015
- H. Osadnik, M. Schöpfel, E. Heidrich, D. Mehner, H. Lilie, C. Parthier, H.J. Risselada, H. Grubmüller, M.T. Stubbs, T. Brüser
The PspF-binding domain PspA1-144 and the PspAF complex -- New insights into the coiled-coil dependent regulation of AAA+ proteins
Mol. Microbiol., 98(4):743-759, 2015 - J. Taubert, B. Hou, H.J. Risselada, D. Mehner, H. Lünsdorf, H. Grubmüller, T. Brüser
TatBC-Independent TatA/Tat Substrate Interactions Contribute to Transport Efficiency
PLoS ONE, 10(3):e011976, 2015 - H.J. Risselada
Simulations Move Toward a Cure for Viral Diseases
Structure, 23(3):439-440, 2015 - D. Milovanovic, A. Honigmann,..., H.J. Risselada, ..., S.W. Hell, G. Van den Bogaart, R. Jahn
Hydrophobic mismatch sorts SNARE proteins into distinct membrane domains
Nature communications, 6:5984, 2015
2014
- H.J. Risselada, Y. Smirnova, H. Grubmüller
Free energy landscape of rim-pore expansion in membrane fusion
Biophys. J., 107: 2287-2295, 2014 - H.J. Risselada, G. Bubnis, H. Grubmüller
Expansion of the fusion stalk and its implication for biological membrane fusion
Proc. Natl. Acad. Sci. USA., 111:11043-110487, 2014
2013
- Y.G. Smirnova, S. Aeffner, H.J. Risselada, T. Salditt, S.J. Marrink, M. Müller, V. Knecht
Interbilayer repulsion forces between tension-free lipid bilayers from simulation
Soft Matter, 9:10705-10718, 2013 - A. Honigmann, G. Van den Bogaart, E. Iraheta, H.J. Risselada, D. Milovanovic, V. Mueller, S. Mueller, U. Diederichsen, D. Fasshauer, H. Grubmüller, S.W. Hell, C. Eggeling, K. Kühnel, R. Jahn
Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment
Nat. Struct. Mol. Biol., 20:679-686, 2013
2012
- H.J. Risselada, G. Marelli, M. Fuhrmans, Y.G. Smirnova, H. Grubmüller, S.J. Marrink, M. Müller
Line-Tension Controlled Mechanism for Influenza Fusion
PLoS ONE, 7:e38302, 2012 - T. Fischer, H.J. Risselada, R.L.C Vink
Membrane lateral structure: The influence of immobilized particles on domain size
Phys. Chem. Chem. Phys., 14:14500-14508, 2012 - H.J. Risselada, H. Grubmüller
How SNARE molecules mediate membrane fusion: Recent insights from molecular simulations
Curr. Opin. Struct. Biol., 22:187-196, 2012
2011
- G. Van den Bogaart, K. Meyenberg K, H.J. Risselada, H. Amin, K.I. Willig, B.E. Hubrich, M. Dier, S.W. Hell, H. Grubmüller, U. Diederichsen, R. Jahn
Membrane protein sequestering by ionic protein-lipid Interactions
Nature, 479:552-55, 2011 - G. Van den Bogaart, S. Thutupalli, H.J. Risselada, M. Holt, D. Riedel, S. Herminghaus, H. Grubmüller, R. Jahn
Synaptotagmin-1: a distance regulator acting upstream of SNARE nucleation?
Nat. Struct. Mol. Biol., 18: 805-812, 2011 - H.J. Risselada, C. Kutzner, H. Grubmüller
Caught in the act: Visualization of SNARE-mediated fusion events in molecular detail
Chembiochem, 12:1049-1055, 2011 - H.J. Risselada, S.J. Marrink, M. Müller
Curvature-dependent elastic properties of liquid-ordered domains result in inverted domain sorting on uni-axially compressed vesicles
Phys. Rev. Lett., 106: 148102, 2011
2010
- A.J. Rzepiela, L.V. Schafer, N. Goga, H.J. Risselada, A.H. de Vries, S.J. Marrink
Reconstruction of atomistic details from coarse grained structures
J. Comp. Chem., 31:1333-1343, 2010 - M. Louhivuori, H.J. Risselada, E. van der Giessen, S.J. Marrink.
Release of stress through mechanosensitive channels in pressurized liposomes
Proc. Natl. Acad. Sci. USA., 107:19856-19860, 2010
2009
- S. Esteban-Martin, H.J. Risselada, J. Salgado, S.J. Marrink
Stability of asymmetric lipid bilayers assessed by molecular dynamics simulations
JACS, 131:15194-15202, 2009 - H.J. Risselada, S.J. Marrink
The freezing process of small lipid vesicles at molecular resolution
Softmatter, 5:4531-4541, 2009 - H.J. Risselada, S.J. Marrink
Curvature effects on lipid packing in liposomes revealed by coarse grained molecular dynamics simulations
Phys. Chem. Chem. Phys., 11:2056-2067, 2009 - O.H.S. Ollila, H.J. Risselada, M. Louhivuori, E. Lindahl, I. Vattulainen, S.J. Marrink
3D Pressure distribution in lipid membranes and membrane-protein complexes
Phys. Rev. Lett., 102:078101, 2009
2008
- H.J. Risselada, S.J. Marrink
The molecular face of lipid rafts in model membranes
Proc. Natl. Acad. Sci. USA., 105:17367-17372, 2008 - S. Baoukina, L. Monticelli, H.J. Risselada, S.J. Marrink, D.P. Tieleman
The molecular mechanism of lipid monolayer collapse
Proc. Natl. Acad. Sci. USA., 105:10803-10808, 2008 - H.J. Risselada, A.E. Mark, S.J. Marrink
The application of mean field boundary potentials in simulations of lipid vesicles
J. Phys. Chem. B, 112:7438-7447, 2008 - V. Knecht, H.J. Risselada, A.E. Mark, S.J. Marrink
Electrophoretic mobility does not always reflect the charge on an oil droplet
J. Colloid. Int. Sci., 318:477-486, 2008
2007
- S.J. Marrink, H.J. Risselada, S. Yefimov, D.P. Tieleman, A.H. de Vries
The MARTINI forcefield: coarse grained model for biomolecular simulations
J. Phys. Chem. B, 111:7812-7824, 2007
2005
- S.J. Marrink, J. Risselada, A.E. Mark
Simulation of gel phase formation and melting in lipid bilayers using a coarse grained model
Chem. Phys. Lip., 135:223-244, 2005
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The campus of TU Dortmund University is located close to interstate junction Dortmund West, where the Sauerlandlinie A 45 (Frankfurt-Dortmund) crosses the Ruhrschnellweg B 1 / A 40. The best interstate exit to take from A 45 is “Dortmund-Eichlinghofen” (closer to South Campus), and from B 1 / A 40 “Dortmund-Dorstfeld” (closer to North Campus). Signs for the university are located at both exits. Also, there is a new exit before you pass over the B 1-bridge leading into Dortmund.
To get from North Campus to South Campus by car, there is the connection via Vogelpothsweg/Baroper Straße. We recommend you leave your car on one of the parking lots at North Campus and use the H-Bahn (suspended monorail system), which conveniently connects the two campuses.
TU Dortmund University has its own train station (“Dortmund Universität”). From there, suburban trains (S-Bahn) leave for Dortmund main station (“Dortmund Hauptbahnhof”) and Düsseldorf main station via the “Düsseldorf Airport Train Station” (take S-Bahn number 1, which leaves every 20 or 30 minutes). The university is easily reached from Bochum, Essen, Mülheim an der Ruhr and Duisburg.
You can also take the bus or subway train from Dortmund city to the university: From Dortmund main station, you can take any train bound for the Station “Stadtgarten”, usually lines U41, U45, U 47 and U49. At “Stadtgarten” you switch trains and get on line U42 towards “Hombruch”. Look out for the Station “An der Palmweide”. From the bus stop just across the road, busses bound for TU Dortmund University leave every ten minutes (445, 447 and 462). Another option is to take the subway routes U41, U45, U47 and U49 from Dortmund main station to the stop “Dortmund Kampstraße”. From there, take U43 or U44 to the stop “Dortmund Wittener Straße”. Switch to bus line 447 and get off at “Dortmund Universität S”.
The AirportExpress is a fast and convenient means of transport from Dortmund Airport (DTM) to Dortmund Central Station, taking you there in little more than 20 minutes. From Dortmund Central Station, you can continue to the university campus by interurban railway (S-Bahn). A larger range of international flight connections is offered at Düsseldorf Airport (DUS), which is about 60 kilometres away and can be directly reached by S-Bahn from the university station.
The H-Bahn is one of the hallmarks of TU Dortmund University. There are two stations on North Campus. One (“Dortmund Universität S”) is directly located at the suburban train stop, which connects the university directly with the city of Dortmund and the rest of the Ruhr Area. Also from this station, there are connections to the “Technologiepark” and (via South Campus) Eichlinghofen. The other station is located at the dining hall at North Campus and offers a direct connection to South Campus every five minutes.
The facilities of TU Dortmund University are spread over two campuses, the larger Campus North and the smaller Campus South. Additionally, some areas of the university are located in the adjacent “Technologiepark”.
Site Map of TU Dortmund University (Second Page in English).